Mechanisms Involved in Trichloroethylene Induced Liver Cancer: Importance to Environmental Cleanup
نویسندگان
چکیده
منابع مشابه
Performance of methylation and expression fluctuations of sonic hedgehog genes in gastric adenocarcinoma
Gastric cancer (GC) is considered as one of the most serious cancers, and in Iran, due to environmental factors in different regions, it has a high frequency. Apart from environmental factors, genetic and epigenetic ones also play a key role in the development of carcinogenesis of GC. In this regard, the study of functioning of the molecular mechanisms involved in the carcinogenesis and also tu...
متن کاملKey Issues in the Modes of Action and Effects of Trichloroethylene Metabolites for Liver and Kidney Tumorigenesis
Trichloroethylene (TCE) exposure has been associated with increased risk of liver and kidney cancer in both laboratory animal and epidemiologic studies. The U.S. Environmental Protection Agency 2001 draft TCE risk assessment concluded that it is difficult to determine which TCE metabolites may be responsible for these effects, the key events involved in their modes of action (MOAs) , and the re...
متن کاملXenobiotic Exposure and Autoimmune Hepatitis
Although genetics contributes to the development of autoimmune diseases, it is clear that "environmental" factors are also required. These factors are thought to encompass exposure to certain drugs and environmental pollutants. This paper examines the mechanisms that normally maintain immune unresponsiveness in the liver and discusses how exposure to certain xenobiotics such as trichloroethylen...
متن کاملMode of action of liver tumor induction by trichloroethylene and its metabolites, trichloroacetate and dichloroacetate.
Trichloroethylene (TCE) induces liver cancer in mice but not in rats. Three metabolites of TCE may contribute--chloral hydrate (CH), dichloroacetate (DCA), and trichloroacetate (TCA). CH and TCA appear capable of only inducing liver tumors in mice, but DCA is active in rats as well. The concentrations of TCA in blood required to induce liver cancer approach the mM range. Concentrations of DCA i...
متن کاملTrichloroethylene and cancer: epidemiologic evidence.
Trichloroethylene is an organic chemical that has been used in dry cleaning, for metal degreasing, and as a solvent for oils and resins. It has been shown to cause liver and kidney cancer in experimental animals. This article reviews over 80 published papers and letters on the cancer epidemiology of people exposed to trichloroethylene. Evidence of excess cancer incidence among occupational coho...
متن کامل